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Index > Protein center > Anpep(Gene name) > Mouse
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  • Anpep (Gene name),
  • Aminopeptidase N (Protein name ),  AMPN_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Anpep(Lap-1;Lap1);
    Protein name:
    Aminopeptidase N(AP-N;mAPN);
    Alternative:
    Aminopeptidase M(AP-M);Alanyl aminopeptidase;Microsomal aminopeptidase;Membrane protein p161;
    CD:
    CD13;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types. May have a role in angiogenesis (By similarity). Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    966
    Sequence:
    50:
    MAKGFYISKT | LGILGILLGV | AAVCTIIALS | VVYAQEKNRN | AENSATAPTL | 
    100:
    PGSTSATTAT | TTPAVDESKP | WNQYRLPKTL | IPDSYRVILR | PYLTPNNQGL | 
    150:
    YIFQGNSTVR | FTCNQTTDVI | IIHSKKLNYT | LKGNHRVVLR | TLDGTPAPNI | 
    200:
    DKTELVERTE | YLVVHLQGSL | VEGRQYEMDS | QFQGELADDL | AGFYRSEYME | 
    250:
    GDVKKVVATT | QMQAADARKS | FPCFDEPAMK | AMFNITLIYP | NNLIALSNML | 
    300:
    PKESKPYPED | PSCTMTEFHS | TPKMSTYLLA | YIVSEFKNIS | SVSANGVQIG | 
    350:
    IWARPSAIDE | GQGDYALNVT | GPILNFFAQH | YNTSYPLPKS | DQIALPDFNA | 
    400:
    GAMENWGLVT | YRESSLVFDS | QSSSISNKER | VVTVIAHELA | HQWFGNLVTV | 
    450:
    AWWNDLWLNE | GFASYVEYLG | ADYAEPTWNL | KDLMVLNDVY | RVMAVDALAS | 
    500:
    SHPLSSPADE | IKTPDQIMEL | FDSITYSKGA | SVIRMLSSFL | TEDLFKKGLS | 
    550:
    SYLHTYQYSN | TVYLDLWEHL | QKAVNQQTAV | QPPATVRTIM | DRWILQMGFP | 
    600:
    VITVNTNTGE | ISQKHFLLDS | KSNVTRPSEF | NYIWIAPIPF | LKSGQEDHYW | 
    650:
    LDVEKNQSAK | FQTSSNEWIL | LNINVTGYYL | VNYDENNWKK | LQNQLQTDLS | 
    700:
    VIPVINRAQI | IHDSFNLASA | KMIPITLALD | NTLFLVKEAE | YMPWQAALSS | 
    750:
    LNYFTLMFDR | SEVYGPMKRY | LKKQVTPLFF | YFQNRTNNWV | NRPPTLMEQY | 
    800:
    NEINAISTAC | SSGLKECRDL | VVELYSQWMK | NPNNNTIHPN | LRSTVYCNAI | 
    850:
    AFGGEEEWNF | AWEQFRNATL | VNEADKLRSA | LACSKDVWIL | NRYLSYTLNP | 
    900:
    DYIRKQDTTS | TIISIASNVA | GHPLVWDFVR | SNWKKLFENY | GGGSFSFANL | 
    950:
    IQGVTRRFSS | EFELQQLEQF | KADNSATGFG | TGTRALEQAL | EKTRANIDWV | 
    966:
    KENKDAVFKW | FTENSS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    Pfam:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse AP-N
    Cat.:
    E9154m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse AP-N
    Cat.:
    E9154h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse AP-N
    Cat.:
    E9154p
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse AP-N
    Cat.:
    E9154c
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse AP-N
    Cat.:
    E9154r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse AP-N
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse AP-N
    Cat.:
    E9154d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse AP-N
    Cat.:
    E9154b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse AP-N
    Cat.:
    U9154p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AP-N
    Cat.:
    U9154h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AP-N
    Cat.:
    U9154m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse AP-N
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse AP-N
    Cat.:
    U9154d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AP-N
    Cat.:
    U9154r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse AP-N
    Cat.:
    U9154b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AP-N
    Cat.:
    U9154c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse AP-N
    Polyclonal Antibody for Mouse AP-N
    Polyclonal Antibody for Mouse AP-N
    Polyclonal Antibody for Mouse AP-N
    Cat.:
    P9154Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AP-N
    Polyclonal Antibody for Mouse AP-N
    Polyclonal Antibody for Mouse AP-N
    Cat.:
    P9154Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AP-N
    Cat.:
    P9154Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse AP-N
    Monoclonal Antibody for Mouse AP-N
    Monoclonal Antibody for Mouse AP-N
    Monoclonal Antibody for Mouse AP-N
    Monoclonal Antibody for Mouse AP-N
    Monoclonal Antibody for Mouse AP-N
    Monoclonal Antibody for Mouse AP-N
    Monoclonal Antibody for Mouse AP-N
    Protein for Mouse AP-N
    Protein for Mouse AP-N
    Protein for Mouse AP-N
    Protein for Mouse AP-N
    Protein for Mouse AP-N
    Protein for Mouse AP-N
    Protein for Mouse AP-N
    Protein for Mouse AP-N

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "p161, a murine membrane protein expressed on mast cells and some macrophages, is mouse CD13/aminopeptidase N."
      Chen H. , Kinzer C.A. , Paul W.E.
      J. Immunol.157:2593-2600(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 538-564; 886-908; 922-942 AND 961-965;TISSUE SPECIFICITY
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Czech II.
      strain: FVB/N.
      tissue: Mammary tumor.
    3. 3.
      "A mouse aminopeptidase N is a marker for antigen-presenting cells and appears to be co-expressed with major histocompatibility complex class II molecules."
      Hansen A.S. , Noren O. , Sjostrom H. , Werdelin O.
      Eur. J. Immunol.23:2358-2364(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYMATIC CLEAVAGE OF ANTIGEN PEPTIDES BOUND TO CLASS II MHC
    4. 4.
      "T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides."
      Larsen S.L. , Pedersen L.O. , Buus S. , Stryhn A.
      J. Exp. Med.184:183-189(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYMATIC CLEAVAGE OF ANTIGEN PEPTIDES BOUND TO CLASS II MHC
    5. 5.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-852;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    6. 6.
      "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
      Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-106; ASN-128; ASN-606; ASN-666; ASN-783; ASN-784; ASN-785; ASN-790 AND ASN-817
      tissue: Myoblast.
    7. 7.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-106; ASN-114; ASN-332; ASN-606; ASN-783; ASN-784; ASN-785 AND ASN-817
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